Major new cancer discovery: Treatment to promote erection could play key role in recovery

According to new prevention research in the UK, scientists have discovered how a family of enzymes used in the development of drugs used to treat erectile dysfunction could enable the effect of chemotherapy in the treatment of oesophageal cancer .

In the first results of the research program published this Tuesday, June 21 in Medicine Reports Unitscientists have discovered that the enzyme intervention mechanism used primarily in the treatment of erectile dysfunction, can reverse the resistance to multiplication and significantly reduce the development of cancerous tumors of the esophagus.

Hope lies in the PDE5 inhibitor, a substance that inhibits the action of the enzyme phosphodiesterase located in the smooth muscle cells lining the blood vessels that notably supply the corpora cavernosa of the penis.

Phosphodiesterase 5 (PDE5) is an enzyme that automatically slows down the mechanism of erection. When this enzyme is inhibited, the erection is prolonged: this is what drugs against erectile disorders like Viagra, the most famous of them, want.

Such cooperation between this treatment for erectile dysfunction and multiplication therefore played a fundamental role in the metastatic evolution of the tumor.

Resistance to fertilization in esophageal cancer is activated by the “tumor microenvironment”, the area that surrounds the tumor. This is made up of molecules, blood vessels and cells such as cancer-associated fibroblasts (CAF), which are important for tumor growth. This “tumor micro-environment” feeds the tumor and can act as a protective cloak, preventing treatments like chemotherapy from having an effect.

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However, it appears that high levels of PDE5 were found in the fibroblasts taken from within the tumor microenvironment proposed to propose to researchers that PDE5 would be an effective target for the treatment of esophageal cancer cells. Clinical trials will now continue to develop an appropriate care protocol in the coming years.

Esophageal cancer treatment by Journal L’Indépendant on Scribd

Because according to the first results, the inhibitors of the PDE5 combined with the potentiation could reduce certain tumors of the esophagus more than the only one, by attacking the resistance to the potentiation, corresponding to one of the main challenges of the treatment of the esophageal cancer. But above all, this advance could pave the way for the use of PDE5 inhibitors in other types of cancer.

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In all likelihood, if a treatment comes out of this program, it could help a significant number of patients around the world. On average, between 8,000 and 9,000 people suffer from esophageal cancer each year in France.

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